But according to Hannah Cohan, a board-certified nurse practitioner with the Medical Offices of Manhattan, Its safer to explore other weight loss options, such as Zepbound (tirzepatide) or Ozempic (semaglutide), which can be used alongside Wellbutrin without the same risk of serotonin-related complications. Qsymia (phentermine/topiramate) and Contrave (bupropion/naltrexone) without Wellbutrin may be safer options purely for weight management
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Current headline medications such as semaglutide and tirzepatide work by mimicking incretin hormones released by the gut after meals
Geneve, Shakira Rodriguez-Gonzalez, Chia Li, Kaitlyn McElhern, Marc L
doi:10.1001/jamadermatol.2025.2723 Image Credit: OpenAI
Once-weekly subcutaneous semaglutide 2.4 mg is approved for weight management in people with obesity and related complications