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Motivation for change may also guide treatment planning

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studies have reported GR activity to be unvaried in erythrocytes of CF children ( Cftr -KO mice (Velsor et al., 2001), and conversely, significantly decreased in CF bronchial epithelial cells compared to WT controls ( Cftr -KO mice and a decrease in CFTR-deficient lung cells, highlighting its vulnerability to oxidative damage in CF (Velsor et al., 2006)