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For example, in a study by Dong et.al, a fluorinated calcium carbonate nanocomposite (PFCE@fCaCO3-PEG) was fabricated by coating amorphous CaCO3 with dopamine-grafted perfluorosebacic acid (DA2-PFSEA) as an organic ligand via a surface-protected etching method in the presence of iron ions, followed by PEGylation, aiming to reverse tumor hypoxia and acidity-induced resistance to radiotherapy [128]