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A high-sodium diet will significantly worsen the fluid retention caused by elevated GH and IGF-1 levels

CJC-1295, injected as a single injection in another study, was effective at increasing GH even one week after application in 20-40 y.o

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This effect may be due either to inhibition of carbamyl phosphate synthase (CPS) I by -oxidation metabolites (CPS I is the first mitochondrial enzymatic step of the urea cycle) or to decreased synthesis of N -acetyl glutamic acid (NAGA) from acetyl-CoA and glutamate by NAGA synthetase (NAGA is an important cofactor of CPS I)