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Despite its potential significance, some studies have not identified statistically significant differences between PD patients and controls [20], suggesting the need for further validation

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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)

Before starting treatment, a full medical review is required to assess suitability