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HSA-binding DARPin consists of two internal ankyrins with flanking constant N- and C-terminal capping repeats, each repeat forming a -turn followed by two anti-parallel -helix and an unstructured loop that binds to the -turn of the next ankyrin repeat (Fig

The ORION studies, with over 12,000 patients, showed strong LDL reduction and only mild injection-site reactions and no major ADR's

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