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Common symptoms include: Chronic pelvic pain , often cyclical and worsening during menstruation Dysmenorrhoea (painful periods) that may be severe and debilitating Dyspareunia (pain during or after sexual intercourse) Subfertility or infertility , affecting approximately 3050% of women with endometriosis [17] Gastrointestinal symptoms such as painful bowel movements, bloating, and altered bowel habit Urinary symptoms including dysuria and frequency Chronic fatigue and reduced quality of life Diagnosis can be challenging, with an average delay of 78 years from symptom onset to confirmed diagnosis in the UK

In the 68-week STEP 1 trial of 1,961 adults without diabetes, mean body weight change was minus 14.9% with semaglutide 2.4 mg versus minus 2.4% with placebo, and 50.5% of the semaglutide group lost at least 15% of body weight

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