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Cancer Res 77(8):20642077 Dai E et al (2020) AIFM2 blocks ferroptosis independent of ubiquinol metabolism
Stacking & Combinations Because its mechanism is NAD+ preservation, the logical research pairing is with the NAD+ pathway : in some research framings, an NNMT inhibitor like 5-Amino-1MQ is discussed alongside NAD+ precursors, on the reasoning that inhibiting the enzyme that drains NAD+ and supplying more NAD+ substrate address the same bottleneck from two directions
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Commonly recognized side effects, such as gastrointestinal symptoms, were also widely reported, lending credibility to the approach
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