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55 In esophageal squamous cell carcinoma (ESCC), QSOX2 promotes disulfide bond formation in TSC2, enhancing its phosphorylation by Akt and activating the mTOR/4E-BP1/c-Myc axis, thereby upregulating CSC markers (e.g., CD44, Notch1) and promoting platinum resistance
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Avoid fried foods, high-fat dairy, and foods high in sugar alcohols (sorbitol, xylitol), which trigger rapid gastric distension and cramping
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