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For patients with a higher BMI or more stubborn metabolic resistance, tirzepatide is often the more powerful lever to pull, adds Holmes
It has been shown to enhance the activity of endogenous antioxidants, including glutathione peroxidase and SOD
( Changes in microbiota composition can affect LPS-induced signaling pathways including TLRs ( via increased pro-inflammatory cytokine production, increased cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase expression
26 Overall, the cardiovascular effects of GLP-1 RAs in HF can be realised through multiple pathways, including reducing visceral fat and EAT in obese HF patients
doi: 10.1073/pnas.1102715108 21 TianJMiddletonBLeeVSParkHWZhangZKimBet al
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