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The models goodness of fit was assessed using Hosmer-Lemeshows test

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The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels

This is one reason its often associated with longevity-focused therapies

A similar increased risk for heart failure was also observed for alogliptin (3.9% vs 3.3% for placebo)