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Proper sterile mixing procedures prevent endotoxin contamination that causes severe reactions

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First, CMap predictions are computational hypotheses generated from cell-line transcriptomes (predominantly MCF-7, HL-60, and PC3 in the original v1/v2 dataset) and require independent biochemical or in vivo validation before they support causal mechanism claims

The main adducts, 8-OHdG and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) are formed when hydroxyl radicals are added to guanine

Washington, DC: Patient-Centered Outcomes Research Institute (PCORI)

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