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SUSTAIN-6 compared semaglutide and placebo in 3,297 people with type 2 diabetes and established cardiovascular disease, chronic kidney disease, or both, or who were aged over 60 years and had subclinical evidence of cardiovascular disease (persistent microalbuminuria or proteinuria, hypertension with left ventricular hypertrophy, left ventricular dysfunction by imaging, ankle/brachial index less than 0.9)
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A slow, 5-10 second injection allows the tissue to expand gradually and accept the fluid without resistance
inflammatory trajectories diverge widely between patient groups, studies, and disease contexts
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