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Numerous subjective indicators from research on DSIP effects in humans suggest that the peptide does indeed promote sleep, inducing feelings of drowsiness, increasing sleep by 59% within a 130-min interval after the treatment, as compared to placebo, and shortening sleep onset as well

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There was also a pilot study in seven people with chronic pain and a single case report in one narcolepsy patient

No large-scale human clinical trials have established what either compound does in people, how they interact with each other in a human context, or what their safety profiles are in human use

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Safety and tolerability data from injection studies show mild side effects (injection site reactions, headache) with no serious adverse events at therapeutic doses