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The mechanism of the possible causality between semaglutide and depression is still unclear

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Joel Habener Massachusetts General Hospital Lotte Bjerre Knudsen Novo Nordisk Svetlana Mojsov The Rockefeller University For the discovery and development of GLP-1-based drugs that have revolutionized the treatment of obesity The 2024 Lasker~DeBakey Clinical Medical Research Award honors three scientists for their discovery and development of GLP-1-based drugs that have revolutionized the treatment of obesity

Some individuals may experience mild side effects such as insomnia, changes in taste, nausea, or mood swings

Because glucose is absorbed in the proximal small intestine, fermentation usually occurs early if overgrowth is present

Patients were randomly allocated to receive subcutaneous injections of semaglutide 2.4 mg, semaglutide 1.0 mg, or placebo once a week for 68 weeks, along with lifestyle intervention