While complete Phase 3 data is pending, the trial design incorporates the escalation framework validated in Phase 2 starting at lower doses and escalating over defined intervals to target maintenance doses
Levy also expressed concern that it could cause weight cycling, or yo-yo dieting repeatedly losing and gaining weight, which can have negative health consequences like a higher risk of dying suddenly from a heart attack
ACS Catalysis 13 , 36273643 (2023)
Instead, coverage is contingent upon a principle known as medical necessity
Tension is a big factor in wound dehiscence and hypertrophic [raised, thick, red] scarring, and this [helps prevent both with] a tension-free closure. Reconnecting each tissue layer that was cut, from the bottom up, also keeps the skin from sticking down to the fascia and creating tethered scars (like those seen after C-sections)
BNF (NICE)