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For instance, combining prednisone with drugs that protect against bone density loss could mitigate one of its most significant long-term risks

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10.3389/fimmu.2021.744129 Front Immunol

A 2025 observational study specifically looking at GLP-1 drug use in people at high risk for sarcopenia found concerning signals even with mitigation attempts [10]

, corticotropin-releasing hormone stimulation test) that may have been helpful will need to be conducted in future prospective trials