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First, an amino acid substitution at position 8 (alanine replaced with aminoisobutyric acid) provides resistance to DPP-4 degradation, the primary enzyme responsible for native GLP-1 breakdown
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Proteases from L onomia obliqua venomous secretions: Comparison of procoagulant, fibrin(ogen)olytic and amidolytic activities
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The decisive chemical advantage is that a small molecule is not subject to peptide bonds that would be enzymatically cleaved in the stomach
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