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Although these findings are compelling, they must be interpreted with considerable caution, as observational studies are inherently limited in their ability to establish causality and are susceptible to multiple forms of bias
The baseline assessment included a detailed sociodemographic data, medical history, frailty status assessment, physical function, cognitive function, nutritional status, and selected frailty biomarkers
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The levels of TMAO are modulated by hepatic FMO3, which is regulated by a bile acid-activated nuclear receptor named the farnesoid X receptor (FXR) 49
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