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The evidence for this is provided by evaluating the liver function biomarkers, CYP2E1 gene expression, iron overload, oxidative stress, SIRT-1 expression and hepatic architecture damage associated with APAP overdose

Tissue injury was graded using a semi-quantitative four-point ordinal severity scale, wherein scores were assigned as follows: Normal Histology = 0, Mild alteration = 1, Moderate alteration = 2, Severe alteration = 3

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A total of 1 10 7 Huh1-sgCtrl or Huh1-sgHNF4-2 cells were injected subcutaneously, and IKE (30 mg/kg) was administered twice weekly for three weeks, starting on day 14 when tumors reached an average volume of 80100 mm 3 (Fig

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