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However, the absence of human clinical trials means the relevance and safety of these mechanisms in humans remains unestablished

Al-Samkari, H

One of the primary mechanisms of immune evasion is the upregulation of the kynurenine pathway, which suppresses the activation and proliferation of effector immune cells ( By combining KP inhibitors with immune checkpoint blockade, it may be possible to enhance the effectiveness of immunotherapy in these resistant tumors

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