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Mice have fundamentally different gut microbiome compositions than humans
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(2011a)
Thats part of what makes this research so compelling: Evidence on GLP-1 drugs and on the benefits of improving insulin sensitivity and reducing inflammation more broadly suggests that getting ahead of metabolic issues, such as type 2 diabetes, early could help people stay healthier as they age
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The anti-obesogenic effect of GLP-1RAs is mediated by direct inhibition of the feeding center and indirectly through modulation of energy expenditure (Jepsen and Christensen 2021)
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