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In rats exposed to a colon cancer-causing chemical, the peptide reduced the number and size of colon tumors, particularly when administered during or after carcinogen exposure

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In 2009, a double-blind randomised-controlled trial (RCT) found significant reductions in duration of outbreaks, the number of ulcers and the level of pain in those on B12, 1000 g per day sublingually (form not reported), regardless of B12 level

And I think thats so important because we do know for sure that the vagus nerve is a bidirectional communicator