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Research utilizing single-cell Raman microspectroscopy has demonstrated that ME/CFS patients exhibit significant aberrations in ROS clearance pathways, including elevated oxidative stress markers and reduced antioxidant enzyme activity

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Gourbal B, Pinaud S, Beckers GJM, Van Der Meer JWM, Conrath U, Netea MG (2018) Innate immune memory: an evolutionary perspective