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For tirzepatide, 79.8% of participants experienced GI events, a figure notably higher than the 25% observed in the control group
Under hypoxic or hyperglycemic conditions, the accumulation of HIF1 markedly drives renal tubular cell ferroptosischaracterized by HO1/TFRC upregulation, iron overload, and lipid peroxidation
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All were observational and used active comparators
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