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Among the main inflammatory mediators, CRP plays a crucial role in atherogenesis by promoting complement activation, enhancing macrophage lipid uptake, stimulating pro-inflammatory cytokine release, inducing monocyte tissue factor expression, impairing endothelial function, and inhibiting nitric oxide production, further aggravating vascular injury (Shrivastava et al

2016;45(8):e293-e298

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Retrieved from Theodorakis, N., Kreouzi, M., Pappas, A., et al

Certain medications can interact with metformin