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AOD-9604 Peptide Synthesized and Lyophilized in Canada by Koi Peptides Domestic Synthesis at a Canadian Facility Assembly of the 16-residue chain is carried out by solid-phase peptide synthesis at a Canadian manufacturing partner, with the Cys7-Cys14 disulfide bond formed during the oxidation step before final purification

Dose escalation planning: Anticipate steady-state changes when transitioning to higher maintenance doses during titration

The underlying questions were ones agency leaders know well: Are we deploying AI well

Nature 583 (7816), 441446

But its strength declines gradually after opening the vial