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The design of high-potency unimolecular GCGR/GLP-1R dual agonists has revolved around substitutions in the mid and C-terminal segments of proposed analogues 5,14,15,16

Synthetic progestins like medroxyprogesterone acetate (MPA) do carry a modest increased risk with prolonged use

Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity

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The remaining authors report no potential competing interests in this work

Gluthome 600 Injection is generally well-tolerated, but mild reactions such as allergic reactions, rash, or irritation at the injection site may occur