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479 Oxidative stress and ROS signaling associated with iron overload may mediate important factors in cardiac hypertrophy and heart failure

We, therefore, used alternative approaches and have determined the structure of a high molecular weight TrxR subfamily member using cryo-EM, demonstrating the feasibility of this methodology to study this protein subfamily of importance in several human diseases (PDB ID 8A1R, EMD-15084) (Fig

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At 75mg daily, most protocols observe metabolic effects within 24 weeks