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For individuals with a BMI 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, or other Asian family origin, or Black African or African-Caribbean family origin) and at least one weight-related comorbidity, GLP-1 receptor agonists such as semaglutide (Wegovy) may be considered through specialist weight management services, subject to the specific criteria and treatment duration outlined in the relevant NICE technology appraisal

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If the levels are chronically high, then there would be a reason to be concerned

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Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors

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