A significant concern is that the most common adverse effects of GLP-1 agonistsnausea, vomiting, diarrhea, and abdominal painoverlap substantially with Crohn's disease symptoms
It is often possible to go back on semaglutide if needed, although some side effects may return at first
Lancet 355 : 517522
Similarly, the highly anticipated EVOKE and EVOKE+ phase 3 trials of oral semaglutide in early Alzheimers disease reported in November 2025 that semaglutide failed to meet its primary endpoints : while it reduced several AD-related biomarkers by up to 10%, these changes did not translate into cognitive or functional benefit ( [72] )
Lee BJ, Lin JS, Lin YC, Lin PT (2015) Anti-inflammatory effects of L-carnitine supplementation (1000 mg/d) in coronary artery disease patients
[12] [13] Medication-induced tremor may result from other drugs, including: Beta-2 agonists (asthma inhalers) Certain antidepressants (SSRIs) Sodium valproate Lithium Excessive caffeine intake Vitamin B12 deficiency should be considered, particularly in patients taking long-term metformin which can reduce B12 levels