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The appropriate amount depends on the form, reason for use, concurrent precursors, medical history and clinician guidance

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Decreased activity of Cu-dependent enzymes, such as SOD, and decreased levels of ceruloplasmin in patients with ME/CFS [371] can be explained by a deficiency in Cu uptake due to overexpression of MTs in enterocytes in response to mucosal infection

10.1126/science.185.4154.862 Science

What is sublingual methyl B12

The standard dosing schedule starts with 0.25 mg weekly for the first four weeks, increases to 0.5 mg weekly from weeks five through eight, and then may escalate to 1 mg or 2 mg weekly depending on tolerance and response