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Animal models may also help to understand these triggers

However, sometimes, the immune system misfires and treats B12 as an invader

Chang 2011)

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Standard route for most peptides

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis