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Direct injectable NAD+ (limited human evidence) Historical IV case reports (O'Holleran 1961) plus pilot pharmacokinetic comparisons (e.g

Reduced liver weight or reduced steatosis-associated features in a diet-induced model should not be interpreted as proof of broad hepatic safety unless supported by appropriate histological assessment, serum chemistry, inflammatory markers, and study-duration-specific monitoring

Injury severity: Minor sprains and small fractures heal better than severe trauma with extensive tissue destruction