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PMID: 22867943
Chattoraj, A., Liu, T., Zhang, L
SHANK3 mutations are likely to cause mitochondrial dysfunction in PMS because six mitochondrial genes, including NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6 ), cytochrome c oxidase assembly ( SCO2 ), tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase ( TRMU ), thymidine phosphorylase ( TYMP ), carnitine palmitoyltransferase 1B ( CPT1B ), and aconitase 2 ( ACO2 ), are adjacent to SHANK3 in the 22q13.3 region [339]
A 1.7-fold increase in physiological L-carnitine levels was previously reported in a mouse model of NASH 15
If semaglutide-related nausea disrupts sleep, try dosing in the morning rather than evening and discuss timing adjustments with your provider
The decrease in cardiovascular events may be related to the effect on reducing blood pressure, or through lowering triglycerides and total cholesterol
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