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Although GLP-1 receptor agonists (GLP-1RAs) were initially developed for the management of diabetes and weight loss, their therapeutic applications have since broadened considerably to encompass a range of cardiovascular, renal, and metabolic disorders [15,16,17]

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12 Combinatorial approaches involving DDR inhibitors, epigenetic modulators, metabolic disruptors and immunotherapeutics hold promise for overcoming resistance and achieving durable clinical responses across malignancies

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We highlighted the summary of the advantages and disadvantages of each route in (Fig