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It has been suggested that these drugs could act through the non-classic RAAS pathways in the context of simultaneous RAAS blockade

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GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

Mood Changes: New or worsening depression or suicidal thoughts