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Effects on the motility of intact spermatozoa and on sperm axonemes
Both agents have demonstrated generally favourable safety profiles in clinical trials, though their side effect patterns differ based on their distinct mechanisms of action
All used primers are listed in Supplementary Table 5
Tirzepatide works similarly to other GLP-1 medications, such as Wegovy (an FDA-approved drug for weight loss) and Ozempic (an FDA-approved drug for type 2 diabetes)
Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)
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