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Amongst the dysregulated mediators, toll-like receptor (TLR) (4), nuclear factor-B (NF-B), and Nod-like receptor pyrin domain-containing (NLRP) (5), as well as the associated TLR/NF-B/NLRP pathway, have been shown to contribute to cancer chemoresistance
However, we did occasionally see the -cells located in the middle of a subset of islets appearing as a double-stained faint glucagon and low-insulin protein (Fig
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