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Mechanism: prescription drugs act directly as GLP-1 receptor agonists
You can read more about Type 2 diabetes on the NHS website Type 2 diabetes
doi: 10.1371/journal.pone.0042938 17 LvJGuoLLiuJJZhaoHPZhangJWangJH
The Bioavailability Question The argument for injections usually comes down to one point: direct injection means more of the peptide reaches your bloodstream
Quick Ranking Table Rank Compound Primary pathway Testosterone relevance 1 hCG LH receptor mimic at Leydig cells Strongest direct clinical testosterone-axis relevance 2 Gonadorelin GnRH signaling to pituitary LH/FSH Strong upstream axis relevance when delivered correctly 3 Kisspeptin-10 Kisspeptin receptor / GnRH activation Strong research signal, less practical clinical availability 4 Sermorelin GHRH receptor / GH release Indirect male-hormone-adjacent research 5 CJC-1295 + Ipamorelin GHRH plus GHS-R1a signaling Indirect recovery and GH-axis research 6 PT-141 Melanocortin receptor pathway Sexual-function relevance, not testosterone production 7 Tesamorelin GHRH analog / GH release Useful comparator, weak direct testosterone relevance 1
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