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Before recommending semaglutide, tirzepatide, or another medically supervised weight-loss strategy, a physician may review weight history, prior weight-loss attempts, BMI, waist circumference, body composition goals, A1C, fasting glucose, insulin-resistance risk, cholesterol, triglycerides, blood pressure, liver enzymes, fatty liver risk, kidney function, current medications, diabetes medication use, history of pancreatitis, gallbladder disease, gastrointestinal symptoms, thyroid history, protein intake, exercise habits, sleep quality, hormonal symptoms, inflammation-related concerns, side-effect tolerance, and long-term maintenance planning
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Consistently, the risk of bias assessment, revealed a moderate risk for the first 6 studies scoring three points, and high risk for the 4 studies scoring five points
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As gastric emptying returns to normal and central appetite suppression diminishes, patients typically experience increased hunger and may resume previous eating patterns
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