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Research involving semaglutide for weight management has observed weight regain among many participants after treatment was withdrawn, but the amount and timing differed
Additionally, liraglutide shifted polarized macrophage phenotype in vitro from the pro-inflammatory M1 phenotype to the M2 anti-inflammatory phenotype
A separate on-treatment SURMOUNT-1 DXA substudy measured fat and lean mass during tirzepatide treatment in 160 participants, 124 of whom received tirzepatide, but it did not study the composition of weight regained after withdrawal
doi:10.1016/j.autrev.2009.02.020 Perrone GG, Dawes IW, Grant CM (2005) Glutathione production
The assessment of gene expression by qPCR was performed as previously described [27, 28]
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