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In vascular dementia (VD), chronic cerebral ischemia drives ferroptosis through dual mechanismsiron metabolism imbalance (upregulation of transferrin and its receptor TfR1 and downregulation of iron export protein FPN) results in the buildup of free iron within neurons, while oxidative stress accelerates lipid peroxidation by inhibiting GPX4 synthesis and upregulating ACSL4
Alpsoy S, Aktas C, Uygur R, et al
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NSL literature pointer PMID 32958033 L-Carnitine laboratory index [PMID: 32958033] National Science Labs indexing note for PMID 32958033: review the PubMed methods, models, and limitations before citing
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