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To investigate the function of CBS in this process, we silenced its expression by CRISPR/cas9 mediated gene knockout strategy (sg CBS ) in SCD erythroblasts (Fig

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doi: 10.3389/fnut.2025.1754492 Received 26 November 2025 Revised 20 December 2025 Accepted 24 December 2025 Published 21 January 2026 Volume 12 - 2025 Edited by Javier Diaz-Castro, University of Granada, Spain Reviewed by Mahsa Rezazadegan, Isfahan University of Medical Sciences, Iran Soroush Taherkhani, Iran University of Medical Sciences, Iran Updates Copyright 2026 Poon, Li, Schweitzer and Akefe