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It incorporates key modifications, including 14E/17R mutations to stabilize an -helical segment via a salt bridge, multiple proline substitutions (25P, 28P, 29P) to reduce -sheet formation, and N-terminal C20 fatty diacid lipidation for reversible albumin binding (Kruse et al

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Panuszko, A., Szymczak, M., Duewska, J., Godlewska, J., Kuffel, A., & Brudziak, P

This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

Natural carotenoids as neuroprotective agents for Alzheimers disease: An evidence-based comprehensive review

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