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The third level is causal proof, such as loss of effect after pathway inhibition or restoration of effect after pathway rescue
Saidi O, Rochette E, Del Sordo G, et al
Constipation occurs because prolonged colonic transit time increases water absorption from stools, making them harder and more difficult to pass
This matters because a diverse, balanced microbiome tends to produce less hydrogen sulfide than one dominated by sulfate-reducing bacteria
Ive been on a GLP-1 and GLP-1/GIP for 12 months, and Im a nutrition coach who was skeptical of this space for a long time
It makes sure you keep getting the benefits of therapy over time
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