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Simultaneously, 3-IAA downregulates the antioxidant enzymes GPX3 and GPX7 in tumor cells, enhancing ROS accumulation and inhibiting autophagy, ultimately sensitizing tumors to chemotherapy
10.1016/j.jep.2018.02.015 270 WarrenA.NyavorY.ZarabianN.MahoneyA.FrameL
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An introduction to cell signalling pathways and their dysregulation in cancer BT - Cell signalling pathways and their therapeutic implication in cancers
Sample volumes were normalized to 35 L with EPPS buffer (200 mM, pH 8), diluted with HPLC grade CH 3 CN (9 L), and then labeled (5 L of 20 g/L per sample) with the corresponding TMTsixplex Isobaric Mass Tag (Themo Scientific, #90064B)