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Considerations: Can cause gastrointestinal side effects, such as oily stools or urgency, especially when combined with high-fat meals

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Increase fluid intake to maximum tolerable levels

The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

Side effects are common, particularly gastrointestinal symptoms like nausea, vomiting, diarrhea, and constipation