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This small size allows them to act quickly and efficiently in the body
Route: Intramuscular injection (into a muscle, such as the gluteus or deltoid) is the most frequent route for this therapy, as it allows the vitamins to be absorbed over time from the muscle depot
Stopping Spironolactone for Acne: Tapering, Rebound & Timeline At a glance Taper duration / 4 to 8 weeks recommended Dose reduction step / 25 mg every 2 to 4 weeks Relapse rate after abrupt stop / approximately 50 to 70% within 6 months Mechanism / competitive aldosterone and androgen receptor antagonist Standard acne dose range / 50 to 200 mg daily Time to initial acne clearance / 3 to 6 months on therapy Potassium monitoring / recheck 1 to 2 weeks after final dose Maintenance alternative / topical retinoid plus azelaic acid FDA pregnancy category / X (contraindicated in pregnancy) Common maintenance dose before taper / 50 to 100 mg daily Why Spironolactone Works for Hormonal Acne Spironolactone blocks androgen receptors in the pilosebaceous unit and inhibits 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT)
Rubbing can spread blood under the skin and worsen bruising
Tang, Y
PMID 29489150
