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However, the UACR reduction was not significantly different (Tuttle et al., 2018)

Abstract The GLP-1 receptor, one of the most successful drug targets for the treatment of type 2 diabetes and obesity, is known to engage multiple intracellular signaling proteins

By quieting down this internal chemical urge and stabilizing reward signaling, GLP-1 drugs effectively dull the intense mental cravings and emotional impulses that trigger a binge episode in the first place